MushroomScience VPS Coriolus Versicolor VPS

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Mushroom Science VPS® Coriolus Versicolor Super Strength 
ALL NATURAL Mushroom Supplements.
MushroomScience Medicinal Mushroom Supplements
Mushroom Supplements- All Natural

Purchase Up To Five Bottles And Pay One Ship Charge $8.85 !! 

You will notice that the label on your Coriolus extract has changed from "VPS" to "Super Strength".  Certified Organic.

The two products are identical except for the following differences;
    1.  The Super Strength is guaranteed at 42% polysaccharide (but tests out at 43-44%), while the VPS was guaranteed at 40% polysaccharide.

     2.  The Super Strengh is extracted from certified organic mushrooms.  The VPS was extracted from mushrooms cultivated through organic practices but not actually certified.

     3.  The Super Strengh is 600 mg per capsule; the VPS was 625 mg per capsule.

Because of the increased potency of the Super Strengh as compared to the UPS the amount of capsules you take will not change.

We chose to make this switch and team up with another manufacturer because our new partner controls much larger quantities of the certified organic raw material and we are switching to certified organic extracts wherever possible.

Mushroom Science Supplement National Distributor

Mushroom Science Medicinal Mushrooms
Mushroom Supplements
The "Super Strength" Coriolus - PSK/Japanese Formula.  Scientifically Proven to Support Immune Defense'
Dehydrated Hot Water Extract.
- 36% beta 1-4, 1-3, 1-6 glucan
(protein-bound polysaccharide)
- Latin ... Coriolus versicolor, Trametes versicolor
- Japanese ... Kawaratake
- Chinese ... Yun zhi
Common Name ... Turkey Tail

Mushroom Supplement Qty / Size
90 vegetarian capsules /
625 mg per Vcap

Mushroom Science VPS Coriolus Versicolor Suggested Use:
1-3 capsules twice daily, AM and PM, or more as recommended by your health care professional. Take on an empty stomach.

Mushroom Science VPS Coriolus Versicolor Mushroom Supplement Product Information:
Over 300 scientific studies and dozens of controlled clinical trials have documented the powerful immune supporting properties of this chemically unique extract from the Coriolus mushroom (beta 1-4, 1-3, 1-6 linkage).
Coriolus Versicolor is the top selling medicinal mushroom in Japan and, worldwide, one of the supplements used most often by those people facing serious immune challenges.

Mushroom Science Coriolus VPS and PSP are used to maintain, protect or restore immune health during and after serious immune challenges.

• We grow our own certified organic mushrooms, on wood, the way nature intended.
• Every extract is carefully prepared, capturing the complete essence of what made these medicinal mushrooms valuable in the ancient herbal traditions of Japan and China.
• Quality is guaranteed; each supplement is formulated to deliver consistent and effective levels of all the primary active compounds identified in the scientific research. Every supplement that carries the MushroomScience label has been analyzed to ensure this is the case.
• Potency is listed on the label of every mushroom supplement, allowing you to take full advantage of the dosing recommendations proven effective in the scientific research.

No other medicinal mushroom supplement company can match our skill, sophistication or experience when it comes to providing you with guaranteed potency, research quality, certified organic mushrooms and mushroom supplements ... the proof is on every label.

MushroomScience is the only mushroom company in North America that is willing to list the levels of all the scientifically validated active compounds on every supplement label.

With tens of thousands of peer reviewed studies published over the last forty years there is no longer any mystery regarding what the active compounds are in each of the different medicinal mushrooms. From Krestin (Coriolus) to Reishi to Maitake, the potency needed for therapeutic effect has been clearly established.

As Dr. Mark Stengler recognizes in his revolutionary new book, "The Health Benefits of Medicine Mushrooms", this potency information is essential, and it is what sets the MushroomScience supplements apart from all other mushroom supplements on the market.

It is only common sense and it is only fair; you need to know this potency information in order to see how the supplement stacks up to the potency standards established in the research.

Consistent and guaranteed potency are the foundation of traditional herbalism and the modern clinical research, and are essential to delivering the health benefits you are looking for when using Mushroom Science Medicinal Mushrooms.

Mushroom Science supplements offer only the very best that nature and science have to offer, and the proof is on every label.

Mushroom Extracts

Coriolus versicolor - VPS^®:  PSK/Japanese Formula. All-Natural.

Agaricus Blazei:  Nature's Most Powerful Beta 1-6 Glucan. All-Natural.

Cordyceps Cs-4 Extract:  For Energy and Endurance. All-Natural.

Immune Builder^®:  The Only Mushroom Combination Product Made From 100% Hot Water Extracts. Organic and All-Natural.

Lion's Mane Extract:  "Brain Booster" TM Formula to Enhance Cognitive Function. All-Natural.

Maitake Full Spectrum Extract:  Organic Maitake Immune Support. Organic.

MaitakeGold 404^®:  Organic Maitake Fraction, Potent Liquid Immune Support. Organic.

PSP-Cloud Mushroom Extract:  From the Famous Cov-1 Strain. Organic.

Reishi Gano 161™:  Premier Longevity Herb of Ancient China Organic.
 

Organic Medicinal Mushrooms

Coriolus versicolor	Reishi	Maitake

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History of Coriolus:

Learning From Traditional Mushroom Supplement Medicine

Of all the medicinal mushrooms we use from Traditional East Asian Medicine the one most studied by modern scientists is probably the one least known outside of Asia.

Commonly known as the "turkey tail" in North America, Coriolus versicolor (also known as Trametes versicolor), is unique among the medicinal mushrooms, with extensive use in both traditional herbalism and modern clinical practice.

The focus of the modern mushroom clinical use and research (over 400 published studies), has been the immuno-modulating properties of the hot water extracted polysaccharides. Originally isolated from the fruiting body (the mushroom), sales for these unique all-natural compounds have reached several hundred million dollars a year in Japan and China, making them the most widely used products in those countries by people facing serious immune challenges (1).

Coriolus versicolor  mushroom is found throughout the wooded temperate zones of North America, Asia, and Europe and may be the most prolific shelf fungus in the Northern Hemisphere. The woody, shelflike fruiting bodies form dense, overlapping clusters on stumps, tree trunks, and fallen trees. The mushroom caps have a plush velvety surface and are colored in varying shades of brown or gray, with a distinctive pattern of alternating bands of dark and light color.

In Classical Chinese and Japanese herbalism the fruit bodies (mushrooms) are harvested, dried, ground to a powder and made into tea(2). Given the extraction rate of the polysaccharides in a simple hot water extract (tea), it is interesting to note that the dose for the active compounds is the same in both traditional medicine and modern clinical practice.

In China Coriolus versicolor is known as "Yun zhi", or the "cloud mushroom". In Japan it is called "Kawaratake", or "mushroom by the river". In traditional herbalism hot water extracts of Coriolus were used to dispel dampness, reduce phlegm, treat pulmonary infections, and to support liver health (3). The Ming dynasty edition of the Materia Medica states that "The black and green Yun zhi are beneficial to one's spirit and vital energy, and strengthen one's tendon and bone. If Yun zhi is taken for a long time, it will make one vigorous and live long." In Japan these mushrooms are also highly prized and sought after by people suffering from a variety of chronic conditions. In fact, it was a neighbor's success in using Coriolus for stomach cancer that first caught the attention of a scientist that worked for the Japanese company Kureha Chemicals, and subsequently launched the research and development of what came to be known as PSK.(4).

Based on its reputation for healing within their traditional herbal practices Chinese and Japanese scientists began to do controlled clinical research on concentrated hot water extracts from Coriolus mushroom, studying the same 1-4, 1-3, 1-6 polysaccharides (beta glucans) that would have been released into solution when making the hot water teas described in the texts from traditional Japanese and Chinese herbalism.

After the placebo controlled, double-blind clinical research demonstrated significant immuno-modulating properties the Coriolus 1-4, 1-3, 1-6 polysaccharides (beta glucans) were approved for use by the Japanese Health Ministry, allowing health insurance to cover the cost of it's use.

At this point the Coriolus Mushroom extract was being prescribed by a significant percent of Japanese M.D.'s. Coriolus polysaccharides were used to support immune health after surgical treatment for various conditions and to support and protect immune health in those patients receiving therapies where immune suppression is a prominent feature. Private and government sponsored research continued to monitor the effectiveness of the highly concentrated Coriolus extract in placebo controlled multi-institutional clinical studies, with the clinical evidence demonstrating significant immune benefit from daily use (5,6,7,8,9,10,11,12).

The Coriolus mushroom extract was so successful that the cost to Japan's national health insurance program reached almost a billion dollars a year. In an attempt to reduce expenditures the Health Ministry restricted the use of the Coriolus extract to those people most in need, people receiving chemotherapy or radiation. Clinical research has consistently demonstrated the ability of Coriolus beta glucans to protect, support, and improve immune function in healthy people and those people recovering from surgery and/or receiving treatments where immune suppression is a prominent feature.

What IsThe Coriolus Versicolor Mushroom ?

There are many chemically distinct extract products that can be produced from the mushroom Coriolus versicolor. VPS® contains the most highly prized and the most difficult to obtain compounds found in Coriolus versicolor, those compounds found in the cell walls of the mushroom and the mycelium (the vegetative form). It is the cell wall extracts that were used in Traditional Chinese Medicine, and it is these same compounds that form the basis of the modern clinical research.

According to the patents and independent lab analysis the following information is available:

NMR Spectrum

Elemental Analysis
Carbon..............................40.5%
Hydrogen...........................6.2%
Nitrogen.............................5.2%
Oxygen............................47.5%

Content Analysis
Soluble carbohydrate.......42%-43% ( 91-93 % beta-glucan containing glucose polymer)
Protein...........................28%-35% ( amino acids)
Moisture.........................7%-7.6%
Ash................................6%-7% ( carbon)
Remainder......................Free Sugars and Amino Acids

U.S. Patent 4,202,969

Protein-Bound Polysaccharides (beta glucans)

The Key
Research with the mushroom Coriolus versicolor has found that the protein-bound polysaccharides with the beta-1,4, beta-1,3 , and beta-1,6 linkage are the primary active compounds.(13, 14). The problem is obtaining significant concentrations of these difficult to extract polysaccharides.

In both the mycelium (the vegetative stage), and the mushroom (the fruiting stage), the cell walls are made of chitin. This material, like the cellulose in higher plants, gives the mushroom it's structural rigidity. This chitin also contains the polysaccharides, the primary active compounds.

Chitin is indigestible by people, therefore the active compounds will not be in a bio-available form in a non-extracted (raw) mushroom product. These polysaccharides are also insoluble in alcohol. Through mastering a technically difficult, multi-step, hot water extraction process, researchers found a way to concentrate the polysaccharides at a level that made large scale production a practical reality.

Only a multi-step hot water extraction process is capable of concentrating these active compounds to levels that make them useful as a nutritional support in chronic conditions. VPS is the only Coriolus product on the North American market manufactured in this manner, and, as compared to other Coriolus products, has a significantly higher concentration of the active polysaccharides.

Quality Control
Every batch of VPS is assayed to guarantee purity and to assure a constant level of the active compounds. No other Coriolus product can match the levels of polysaccharides contained in VPS, and no other mushroom product can top the purity of VPS.

How Does It Work?

The cell wall extract from Coriolus versicolor has been clinically proven to stimulate and enhance the effectiveness of the bodies own natural defenses, a critically important step in maintaining good health.

In one particular study Coriolus polysaccharides were given to both healthy volunteers and to patients with gastric cancer, and the polysaccharides stimulated a significant immune response within 24 hours.(15) In another study workers in a chemical plant were given the polysaccharides for a period of eight weeks. Significant enhancement of NK cell activity was noted along with other significant improvements in immune parameters, with the study concluding that Coriolus polysaccharides "potentiate the immunity of non-tumor bearing individuals with depressed immunity."(16)

Enhanced Immune Function
Every herbal extract contains a number of "major" and "minor" chemical components. It is important to note that it is the effect of all of these components working together that creates the desired effect, and that minor components will play a crucial role in determining the effectiveness of the primary active compounds.

In Coriolus versicolor the primary active compounds are polysaccharides. These polysaccharides are composed of a unique combination of amino acids and beta-glucans that are not affected by the digestive process and are therefore effective when used orally.

Different physiochemical parameters, such as solubility, primary structure, molecular weight, and branching all play an important role in determining the immune activities of polysaccharides.

The polysaccharides found inside the indigestible cell walls of Coriolus versicolor are "three dimensional", with side chains branching off a backbone structure of linear glucose molecules. It is these secondary structures, the branching side chains, that confer biological function or immune activity allowing a " key and lock" interaction between the branching side chains and the receptors on the different immune cells.

Receptors for beta-glucans have been found on a number of different immune cells including natural killer cells and neutrophils, (17,18) monocytes/macrophages, (19) and on T and B lymphocytes (20).

However, Coriolus has multiple pathways for stimulating an immune response. Coriolus polysaccharides have also been shown to stimulate the antigen-presenting cell function of macrophages and, consequently, to stimulate overall immune function (21). Several studies have also reported the ability of Coriolus polysaccharides to enhance in vitro proliferation of T and B lymphocytes (22), and to enhance the cytotoxic activity of NK cells (23).

Recent U.S. research has confirmed these immuno-modulating properties, specifically, these polysaccharides acted as a potent inducer of proliferation, tumor cytotoxicity, and lymphokine production by human lymphocytes in in vitro studies(24).

Clinical Studies
The clinical research conducted with Coriolus polysaccharides is extensive and unique among medicinal mushrooms.

As part of the Japanese Health Ministry's approval process the 1-4, 1-3, 1-6 Coriolus polysaccharides went through 24 human clinical trials with 14 controlled, randomized, double blind human clinical studies. Coriolus polysaccharides are the most thoroughly researched and most successful all-natural immune supplement in the world and the only immune product to be proven in independent, published clinical studies.

Coriolus vs. Placebo
The use of Coriolus polysaccharides to support immune health was studied in a randomized, controlled, clinical trial after curative surgery for colon cancer. The follow up time was ten years. The researchers found that, when compared with the control group (surgery only), the leukocyte activity of the Coriolus group showed "remarkable enhancement".

It was concluded that "the beneficial effects were probably due to the activation of leukocyte functions as one of the many biological-response-modifying activities induced by (Coriolus polysaccharides)"(25). This improvement in immune function was found to be statistically significant and beneficial.

Coriolus Combined With Other Therapies
Controlled clinical studies have also found Coriolus polysaccharides to be effective in supporting immune health in those people receiving treatments where immune suppression is a prominent feature, showing the ability to "inhibit disorders of cellular immunity attributed to" the treatments (26, 27).

A five year study published in Lancet found that those patients receiving Coriolus polysaccharides experienced a significant improvement over the control group (28). Researchers found the Coriolus polysaccharides to have a "restorative effect in patients who have been immuno-suppressed".

Coriolus polysaccharides have also been studied for their immuno-restorative effect in those people receiving radiation treatment after surgery for non-small cell lung cancer. This study found that the "five-year survival rate of the patients (who received Coriolus polysaccharides) with stages I or II disease, as well as stage III, was 39% and 22% respectively, compared with the non-administered groups' 16% and 5%. These differences are statistically significant."(29) Stage III patients that received Coriolus polysaccharides along with radiation had a better survival rate than stage I patients receiving radiation alone (22% vs. 16%).

References

1. Stamets P., Wu Yao C. Mycomedicinals, MycoMedia Publications (1998).
2. Liu B., Bau Y. , Fungi Pharmacopoeia , Kiniko Press, (1980)
3. Jianzhe Y., Xiaolan M., Qiming M., Yichen Z., and Huaan W. Icons of Medicinal Fungi from China, Science Press, Beijing (1987).
4. Tsukagoshi S., Hashimoto Y., Fujii G., Kobayashi H., Nomoto K. and Orita K. Krestin (PSK). Cancer Treat. Rev. 11:131-155 (1984).
5. Torisu M., Hayashi Y., Ishimitsu T., Fujimura T., Iwasaki K., Katano M., Yamamoto H., Kimura Y., Takesue M., Kondo M., and Nomoto K. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colon cancer. Cancer Immunology Immunotherapy, 31:261-268 (1990).
6. Hayakawa K., Mitsuhashi N., Saito Y., Takahashi M., Katano S., Shiojima K., Furuta M., and Niibe H. Effect of Krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer. Anticancer Research, 13:1815-1820 (1993).
7. Ilino Y., Yokoe T., Maemura M., Horiguchi J., Takei H., Ohwada S., and Morishita Y. Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer. Anticancer Research 15:2907-2912 (1995).
8. Nagao T., Komatsuda M.., Yamauchi K.., Nozaki H.., Watanabe K.., Arimori S. Chemoimmunotherapy with Krestin (Coriolus)in Acute Leukemia. Tokai J Exp Med., Vol. 6. No. 2, pp.141-146, 1981.
9. Nakazato H., Koike A., Saji S. et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Lancet, 343-1122-1126 (1994).
10. Hu, Y., et al . Pharamacological Studies of the Effects of PSP on Analgetic Action and Appetite Improvenent. PSP International Symposium, 125-131 (1993).
11. Yang, M., et al .The Anti-tumorous Function and Clinical Significance of Yun Zhi Essence. PSP International Symposium, 221-223 (1993).
12. Yang, Q., et al .The Comparative Analysis of the Extracts of the Mycelia and the Fruitbodies of Yun Zhi (Coriolus versicolor). PSP International Symposium, 41-55 (1993).
13. Hotta et al.U.S. Patent #4,271,151 (1981).
14. Yang, Q., et al .The Comparative Analysis of the Extracts of the Mycelia and the Fruitbodies of Yun Zhi (Coriolus versicolor). PSP International Symposium, 41-55 (1993).
15. Kato, Michio, et al. Induction of gene expression for immunomodulating cytokines in peripheral blood mononuclear cells in response to orally administered PSK, an immunomodulating protein-bound ploysaccharide. Cancer Immunol Immunother. 40:152-156 (1995).
16. Yamakido, Michio, et al. Changes of Human Immunological Parameters by PSK Administration. Hiroshima Journal of Medical Scienses. December, 1984:793-800
17. Di Renzo L., Yefenof E., and Klein E. The function of human NK cells is enhanced by b-glucan, a ligand of CR3 (CD11b/CD 18). Eur. J. Immunol. 21:1755-1758 (1991).
18. Gotoh K., Gouchi A., Akura Y., Tanaka N. and Orita K. Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers. Int. J. Immunopharmac. 5:485-492, 1991.
19. Czop J. K. 1986. The role of b-glucan receptors on blood and tissue leukocytes in phagocytosis and metabolic activation. Pathol. Immunopathol. Res. 5:286-296 (1986).
20. Ohmori K., and Oka T. Effects of OK-432 or PSK on in vitro activation of T-lymphocytes from human peripheral b lood. Biotherapy (Tokyo); 4:712-716 (1990).
21. Di Renzo L., Yefenof E., and Klein E. The function of human NK cells is enhanced by b-glucan, a ligand of CR3 (CD11b/CD18). Eur. J. Immunol. 21:1755-1758 (1991).
22. Gotoh K., Gouchi A., Akura Y., Tanaka N. and Orita K. Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers. Int. J. Immunopharmac. 5:485-492, 1991.
23. Tsukagoshi S., Hashimoto Y., Fujii G., Kobayashi H., Nomoto K. and Orita K. Krestin (PSK). Cancer Treat. Rev. 11:131-155 (1984).
24. Cesano A., and Santoli D., The Wistar Institute, Philadelphia, PA, unpublished results.
25. Torisu M., Hayashi Y., Ishimitsu T., Fujimura T., Iwasaki K., Katano M., Yamamoto H., Kimura Y., Takesue M., Kondo M., and Nomoto K. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colon cancer. Cancer Immunology Immunotherapy, 31:261-268 (1990).
26. Nakazato H., Koike A., Saji S. et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Lancet, 343-1122-1126 (1994).
27. Hu, Y., et al . Pharamacological Studies of the Effects of PSP on Analgetic Action and Appetite Improvenent. PSP International Symposium, 125-131 (1993).
28. Nakazato H., Koike A., Saji S. et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Lancet, 343-1122-1126 (1994).
29. Hayakawa K., Mitsuhashi N., Saito Y., Takahashi M., Katano S., Shiojima K., Furuta M., and Niibe H. Effect of Krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer. Anticancer Research, 13:1815-1820 (1993).

Known as Krestin or PSK in Japan, and as PSP or Yun zhi in China, the hot water extract of this medicinal mushroom is the world's most thoroughly researched supplement for serious immune challenges. There have been more than 400 animal studies and over a dozen placebo-controlled double-blind human clinical studies published in peer reviewed medical journals.

Mushroom Science is the only company in North America offering their customers research quality PSK (VPS) and PSP, and has been acting as a consultant for the recently funded $1,000,000.00 study on these extracts.